The LP640 version was presented in march 2006 at the Geneva Motor Show . As a facelift for the coupé version. It features a 6.5 Liter engine, now producing 472 kW (642 PS/633 bhp), improving performance substantially. Like the base Murciélago, the engine is mounted "backwards", with the transmission in front of the engine and the differential behind it, instead of a transaxle normally seen on mid-engine cars. There were also a few minor external changes, primarily to the low air intakes.
For the Murciélago LP640, developers added the option of iPod and USB connection, satellite navigation and perforated leather or the steering wheel. Those interested in purchasing the Roadster, because you can hear the music while you drive your car. And can go anywhere guide with satellite navigation. The final update is the new carbon weave that lines the base of the steering wheel and the gear levers in models equipped with the e-gear transmission. inside the LP640, the seating has been reshaped to accommodate greater headroom, while an upgraded instrument panel is flanked by an improved stereo system.